Oligonucleotides for modulation of target RNA activity
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United States of America Patent
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Mar 22, 2016
Grant Date -
Dec 3, 2015
app pub date -
Aug 20, 2015
filing date -
Nov 23, 2010
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Abstract
The present invention relates to oligonucleotides for modulation of target RNA activity. Thus, the invention provides oligonucleotides that bind to microRNA binding sites of target RNA. The oligonucleotides may activate RNase H or RNAi. In a preferred embodiment, the oligonucleotides prevents a micro RNA from binding to its binding site of the target RNA and thereby prevent the microRNA from regulating the target RNA. Such oligonucleotides have uses in research and development of new therapeutics.
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