Compounds and methods for treating inflammatory and fibrotic disorders
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United States of America Patent
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Mar 22, 2016
Grant Date -
Aug 21, 2014
app pub date -
Apr 28, 2014
filing date -
Jun 3, 2008
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Abstract
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
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