Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression

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United States of America Patent

PATENT NO 9289481
SERIAL NO

12560321

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Abstract

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The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product. In one embodiment, where the bacterium is a gram negative host, the recombinant gene product provides for reduced toxicity of LPS. In one embodiment, the gene product is a bacteriophage protein, such as endolysin, holin, or ndd.

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Patent Owner(s)

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BACTOCLEAR HOLDINGS PTE LTD1 ROBINSON ROAD #17-00 AIA TOWER SINGAPORE

International Classification(s)

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  • 2009 Application Filing Year
  • A61K Class
  • 10313 Applications Filed
  • 6747 Patents Issued To-Date
  • 65.43 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances200920102011201220132014201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Padmanabhan, Sriram Sanjaynagar, IN 47 792
Ramachandran, Janakiraman Palo Alto, US 10 177
Sriram, Bharathi Sanjaynagar, IN 21 133

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  • 2 Citation Count
  • A61K Class
  • 38.16 % this patent is cited more than
  • 9 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges6209860894426710349291291182201 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0500100015002000250030003500400045005000550060006500700075008000850090009500

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