Incapacitated whole-cell immunogenic bacterial compositions produced by recombinant expression
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United States of America Patent
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Mar 22, 2016
Issued Date -
N/A
app pub date -
Sep 15, 2009
filing date -
Nov 14, 2002
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to deliver antigens in a manner resembling the live infectious organism in terms of elicitation of a robust immune response, but with reduced risk or no risk of disease. The compositions of the invention are produced by rendering a bacterium bacteriostatic through expression of a recombinant promoter in the bacterial cell, which promoter can be operably linked to a polynucleotide encoding a recombinant gene product. In one embodiment, where the bacterium is a gram negative host, the recombinant gene product provides for reduced toxicity of LPS. In one embodiment, the gene product is a bacteriophage protein, such as endolysin, holin, or ndd.
First Claim
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Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
BACTOCLEAR HOLDINGS PTE LTD | 1 ROBINSON ROAD #17-00 AIA TOWER SINGAPORE |
International Classification(s)

- 2009 Application Filing Year
- A61K Class
- 10313 Applications Filed
- 6747 Patents Issued To-Date
- 65.43 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Padmanabhan, Sriram | Sanjaynagar, IN | 47 | 792 |
# of filed Patents : 47 Total Citations : 792 | |||
Ramachandran, Janakiraman | Palo Alto, US | 10 | 177 |
# of filed Patents : 10 Total Citations : 177 | |||
Sriram, Bharathi | Sanjaynagar, IN | 21 | 133 |
# of filed Patents : 21 Total Citations : 133 |
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Patent Citation Ranking
- 2 Citation Count
- A61K Class
- 38.16 % this patent is cited more than
- 9 Age
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11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 22, 2027 |
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