Device and method for monitoring crystallization
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Mar 15, 2016
Grant Date -
Jun 6, 2013
app pub date -
Jun 30, 2011
filing date -
Jul 1, 2010
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
A method for crystallizing a substance dissolved in a solvent, including the following steps: introducing a solvent volume containing the substance into a chamber having a preset temperature, humidity, and gas composition, adding a predetermined volume of a precipitant to the solvent volume containing the substance, allowing the solvent to evaporate while simultaneously observing structural changes in the solvent volume containing the substance and the precipitant by means of dynamic light scattering, detecting weight changes and determining the molarities, making an association with the location in the phase diagram on the basis of the DLS measurement and the results of the molarity determination, allowing a predetermined number of crystal nuclei to form by adding solvent or adding precipitant, putting the solvent volume containing the substance and the precipitant into a metastable state by adding solvent and/or protein solution or by allowing the concentration of the dissolved substance to decrease by allowing nucleation cores to form, maintaining the metastable state by adding a predetermined amount of the substance to the solvent volume containing the substance and the precipitant or allowing the solvent to evaporate until at least one crystal of a predetermined size is formed.
First Claim
Other Claims data not available
Family
International Classification(s)
- 2011 Application Filing Year
- C30B Class
- 359 Applications Filed
- 298 Patents Issued To-Date
- 83.01 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 1 Citation Count
- C30B Class
- 17.78 % this patent is cited more than
- 9 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 15, 2027 |
