Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
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Mar 8, 2016
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Mar 26, 2014
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Feb 4, 2010
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Abstract
Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-γ-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
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