Peptide linkers for effective multivalent peptide binding
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United States of America Patent
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Mar 8, 2016
Grant Date -
Aug 28, 2014
app pub date -
Feb 27, 2014
filing date -
Dec 18, 2008
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Abstract
Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
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