Method for optical measuring variations of cell membrane conductance
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United States of America Patent
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Mar 1, 2016
Grant Date -
Jun 14, 2012
app pub date -
Jul 16, 2010
filing date -
Jul 20, 2009
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Abstract
The instant invention refers to an optical method to extrapolate cell membrane conductance by indirect measurement of changes in transmembrane voltage, upon exposure of a cell sample to electric current pulses. The method is advantageously used for evaluating the activity of molecules able to alter, directly or indirectly, membrane permeability. A specific field of application is the screening of candidate compounds putatively acting on ion channel activity. In particular, it is open to the study of all ion channels with no limitations on the mechanisms of activation or to the ion species involved. The method is also advantageously used for evaluating a cell status, namely a differentiative or a pathologic status.
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