Crystal of recombinant interferon with altered spatial configuration, three-dimensional structure and uses thereof
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United States of America Patent
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Mar 1, 2016
Grant Date -
Dec 4, 2014
app pub date -
Aug 15, 2014
filing date -
Dec 18, 2009
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Abstract
This invention provides crystalline recombinant interferon (rSIFN-co (SEQ ID NO: 1)) having (i) the same amino acid sequence as that of human consensus interferon, and (ii) altered three-dimensional structure as compared to IFN-α2b. The interferon of the present invention exhibits enhanced biological activities. The present invention also provides a structural model of said interferon useful for drug screening and/or drug design, and mimetics of said interferon.
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