Hydroxy acid ester compound of substituted phenol, preparation method and medical use thereof
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United States of America Patent
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Mar 1, 2016
Grant Date -
Mar 28, 2013
app pub date -
Oct 13, 2010
filing date -
Jun 23, 2010
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Abstract
Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y═C1-4 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.
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