Method of inhibiting nonsense-mediated mRNA decay

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United States of America Patent

PATENT NO 9271998
APP PUB NO 20140073685A1
SERIAL NO

14082346

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Abstract

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Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased.

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Patent Owner(s)

Patent OwnerAddress
RUTGERS THE STATE UNIVERSITY OF NEW JERSEYNEW BRUNSWICK NEW JERSEY 08903

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hanauske-Abel, Hartmut M Edgewater, US 17 76
Hoque, Mainul North Arlington, US 6 22
Mathews, Michael B Montclair, US 36 2028
Pe'ery, Tsafi Montclair, US 5 25

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