STXBP1 overexpressing mouse and its uses in screening of treatments for neuropsychiatric illness
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United States of America Patent
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Feb 23, 2016
Grant Date -
Nov 3, 2011
app pub date -
Aug 18, 2009
filing date -
Aug 20, 2008
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Abstract
A non-human transgenic animal having a polynucleotide encoding an STXBP1 polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the STXBP1 polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illness are disclosed.
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