Formulations for a tight junction effector
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United States of America Patent
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Feb 23, 2016
Grant Date -
Aug 23, 2007
app pub date -
Feb 9, 2007
filing date -
Feb 9, 2006
priority date (Note) -
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Abstract
Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine.
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