Rapid and accurate analysis of protein sialylation
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United States of America Patent
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Feb 16, 2016
Grant Date -
Jun 12, 2014
app pub date -
Jul 5, 2012
filing date -
Jul 14, 2011
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Abstract
The invention relates to methods and kits for the analysis of the sialylation of gluco-proteins. The samples of gluco-protein are incubated separately under three conditions: with beta-galactosidase, with beta-galactosidase+alpha-sialidase, and without an enzyme. After the enzyme treatment, high performance anion exchange chromatography with pulsed amperometric detection (HPAEC PAD) is used to make a quantitative determination of the total galactose in the sample, the non sialylated galactose and the exogenous galactose in the medium. The determination of said values makes it possible to deduce the percentage of sialylation of the gluco-protein.
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