Metallo-β-lactamase inhibitors
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United States of America Patent
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Feb 16, 2016
Grant Date -
Mar 22, 2012
app pub date -
Nov 29, 2011
filing date -
Sep 22, 2005
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Abstract
A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
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