Treatment of disease
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United States of America Patent
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Feb 2, 2016
Grant Date -
Jan 16, 2014
app pub date -
Jun 26, 2013
filing date -
Nov 22, 2004
priority date (Note) -
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Abstract
The invention relates to the use of angiogenin, or a fragment or variant thereof, to treat diseases or conditions characterised by neuronal injury or death, or axonal degeneration, especially neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). The invention also describes a plurality of mutations of the human angiogenin gene which are associated with a neurodegenerative disease phenotype, and particularly a ALS phenotype. Also described is a method of assessing whether an individual is afflicted with, or generically predisposed to develop, a disease or condition characterised by neuronal injury or death, or axonal degeneration.
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