Human growth hormone receptor antagonist antibodies and methods of use thereof
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United States of America Patent
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Feb 2, 2016
Grant Date -
Dec 4, 2014
app pub date -
Dec 10, 2012
filing date -
Dec 22, 2011
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Abstract
The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.
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