Stabilized immune modulatory RNA (SIMRA) compounds for TLR7 and TLR8

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United States of America Patent

PATENT NO 9243050
APP PUB NO 20140308300A1
SERIAL NO

14284938

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Abstract

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The invention relates to the therapeutic use of stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides RNA based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.

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Patent Owner(s)

Patent OwnerAddress
IDERA PHARMACEUTICALS INC167 SIDNEY STREET CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agrawal, Sudhir Shrewsbury, US 223 8509
Kandimalla, Ekambar R Southboro, US 70 1668
Lan, Tao Arlington, US 15 151
Li, Yukui Newton, US 15 412
Putta, Mallikarjuna Burlington, US 20 174
Wang, Daqing Bedford, US 91 766
Yu, Dong Westboro, US 354 6818

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