Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates

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United States of America Patent

PATENT NO 9242986
APP PUB NO 20140243521A1
SERIAL NO

14272823

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Abstract

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A synthesis approach providing an early ring attachment via a bromination to compound 1-1 yielding compound II-II, whereby a final product such as AA can be synthesized. In particular, the 2,4-difluorophenyl-containing sidechain is attached before creation of the additional ring Q.

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Patent Owner(s)

Patent OwnerAddress
VIIV HEALTHCARE COMPANY251 LITTLE FALLS DRIVE WILMINGTON DE 19808

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kawasuji, Takashi Osaka, JP 45 683
Nagamatsu, Daiki Osaka, JP 6 89

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