Photochemical internalisation of kinase inhibitors
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United States of America Patent
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Jan 26, 2016
Grant Date -
Dec 1, 2011
app pub date -
Jun 26, 2009
filing date -
Jun 30, 2008
priority date (Note) -
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Abstract
The present invention relates to a method for enhancing the activity of kinase inhibitors in target cells, and more specifically for enhancing the activity of tyrosine kinase inhibitors (TKIs), said method comprising contacting a cell with a kinase inhibitor and a photosensitizing agent and irradiating said cell with light of a wavelength effective to activate the photosensitizing agent, and to the use of this method for enhancing the effects of kinase inhibitors or kinase inhibitor-based drugs in particular to achieve cell death, for example, in cancer treatment and other diseases or conditions in which kinase inhibitors, such as TKIs, have a beneficial effect.
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