Benzalkonium chloride compositions for inhibiting the hydrolytic activity of endogenous matrix metalloproteinases in dental restorations
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United States of America Patent
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Jan 19, 2016
Grant Date -
Aug 25, 2011
app pub date -
Feb 24, 2011
filing date -
Feb 24, 2010
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Abstract
The present application relates to dental adhesive and restoration compositions comprising benzalkonium chloride, having the general structure C6H5CH2N(CH3)2—R—Cl, and salts thereof in a range between approximately 0.01% and approximately 10% by weight in dental primer, dental adhesive, dental resin, and other dental polymeric compositions or in dental solutions. In particular, it has been shown that dental compositions comprising benzalkonium chloride result in the inhibition of the hydrolytic activity of MMP on the dentin adhesive layer, thereby reducing the degradation of bond strength between a resulting dental restoration and the underlying dental tissue.
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