Polypeptide variants of sleeping beauty transposase

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United States of America Patent

PATENT NO 9228180
SERIAL NO

12667527

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Abstract

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The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these variants, to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using these hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB) and to transposons used in the inventive gene transfer system, comprising a nucleic acid sequence with flanking repeats (IRs and/or RSDs). Furthermore, applications of these transposase variants, the transpsoson, or the gene transfer system are also disclosed such as gene therapy, insertional mutagenesis, gene discovery (including genome mapping), mobilization of genes, library screening, or functional analysis of genomes in vivo and in vitro. Finally, pharmaceutical compositions and kits are also encompassed.

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Patent Owner(s)

Patent OwnerAddress
MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN13125 BERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ivics, Zoltan Berlin, DE 15 367
Izsvak, Zsuzsanna Berlin, DE 12 356
Judis, Carmen-Anisia Berlin, DE 4 31
Katzer, Andrea Wandlitz, DE 4 31
Manoj, Namitha Louisville, US 4 31
Mates, Lajos Berlin, DE 4 31

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