Myonectin (CTRP15), compositions comprising same, and methods of use
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United States of America Patent
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Jan 5, 2016
Grant Date -
Dec 18, 2014
app pub date -
Jan 24, 2013
filing date -
Jan 26, 2012
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Abstract
Disclosed is the novel myokine known as myonectin (CTRP15), an isolated nucleic acid encoding the myonectin (CTRP15) gene, and the amino acid sequence encoding the myonectin (CTRP15) protein. Methods of isolation of the nucleic acid, protein, polypeptides and methods of making antibodies to the myonectin (CTRP15) protein are provided. The use of myonectin (CTRP15) in the modulation of lipid and/or glucose metabolism, suppressing the expression of autophagy genes, inhibiting LC3 lipidation and autophagosome-dependent p62 degradation, and activating the Akt/mTOR pathway is also provided.
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