Covalent inhibitors of Kras G12C

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United States of America Patent

PATENT NO 9227978
SERIAL NO

14212656

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Abstract

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Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.

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Patent Owner(s)

Patent OwnerAddress
ARAXES PHARMA LLC3033 SCIENCE PARK ROAD SUITE 220 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Feng, Jun San Diego, US 210 4080
Li, Liansheng San Diego, US 158 5429
Liu, Yi San Diego, US 838 10296
Ren, Pingda San Diego, US 198 6390
Wu, Tao Carlsbad, US 372 4736

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