Histone inhibition
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United States of America Patent
Stats
-
Jan 5, 2016
Grant Date -
Dec 19, 2013
app pub date -
Nov 29, 2011
filing date -
Dec 1, 2010
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.
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Cited Art Landscape
Patent Citation Ranking
- 1 Citation Count
- A61K Class
- 38.16 % this patent is cited more than
- 9 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 5, 2027 |
