Spirocyclic molecules as protein kinase inhibitors
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United States of America Patent
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Jan 5, 2016
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Aug 28, 2014
app pub date -
Jul 26, 2012
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Jul 27, 2011
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Abstract
The present invention relates to spirocyclic compounds of formula I, namely spirocyclic (1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amines having protein kinase inhibitory activity, and methods of synthesizing and using such compounds. Preferred compounds are c-Met and/or ALK inhibitors useful for the treatment of abnormal cell growth, such as cancers.
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