Compositions and methods for silencing genes expressed in cancer
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United States of America Patent
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Dec 29, 2015
Grant Date -
Mar 14, 2013
app pub date -
Sep 23, 2010
filing date -
Sep 23, 2009
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Abstract
The present invention provides therapeutic nucleic acids such as interfering RNA (e.g., siRNA) that target the expression of genes associated with tumorigenesis and/or cell transformation, lipid particles (e.g., nucleic acid-lipid particles) comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles, e.g., for the treatment of a cell proliferative disorder such as cancer.
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