Use of a fluorinated polymer as a contrast agent in solid state 19F magnetic resonance imaging (MRI), scaffold comprising said polymer and use thereof
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United States of America Patent
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Dec 29, 2015
Grant Date -
Jun 14, 2012
app pub date -
Dec 2, 2011
filing date -
Dec 3, 2010
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Abstract
A method of using a fluorinated polymer having a glass transition temperature below 40 C as a contrast agent in 19F magnetic resonance imaging (MRI) of a solid object, said solid object comprising said contrast agent. The invention relates to a solid object comprising a structural component and an imaging component, wherein the imaging component is at least one fluorinated polymer. The invention relates to a method for 19F MRI in solid state using a contrast agent comprising a fluorinated polymer as well as a method for in vivo visualizing a scaffold. It further relates to a method for in vivo monitoring the degradation of a solid object in time, wherein the degradation is monitored in time by using 19F MRI to visualize the solid object, and wherein the amount of degradation of the solid object is determined based on the decrease in the visibility of the amount of 19F.
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