Lipopeptides for delivery of nucleic acids

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United States of America Patent

PATENT NO 9220785
SERIAL NO

13715768

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Abstract

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Lipopeptide compounds with a central peptide and having lipophilic groups attached at each terminus, and salts and uses thereof. The lipophilic groups can be derived from a naturally-occurring lipid, or can be a C(1-22)alkyl, C(6-12)cycloalkyl, C(6-12)cycloalkyl-alkyl, C(3-18)alkenyl, C(3-18)alkynyl, C(1-5)alkoxy-C(1-5)alkyl, or a sphinganine, or (2R,3R)-2-amino-1,3-octadecanediol, icosasphinganine, sphingosine, phytosphingosine, cis-4-sphingenine. The compounds can be used in compositions to deliver active agents to cells, including interfering-RNA agents and antisense RNAs.

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Patent Owner(s)

Patent OwnerAddress
MARINA BIOTECH INCBOTHELL WA 98021-7266

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adami, Roger C Bothell, US 31 333
Houston,, Jr Michael E Sammamish, US 36 267
Johns, Rachel E Shoreline, US 9 36

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