GLP-1 receptor agonist compounds having stabilized regions
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United States of America Patent
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Dec 22, 2015
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Jul 18, 2013
app pub date -
Jul 27, 2011
filing date -
Jul 28, 2010
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Abstract
The disclosure provides GLP-1 receptor agonist compounds having stabilized regions corresponding to alpha-helical regions of the natural peptide compounds. The disclosure also provides benzamide-containing exendin-4 analogs and alkene-constrained exendin-4 analogs, both of which have stabilized regions corresponding to alpha-helical regions of exendin-4.
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