Activated sialic acid derivatives for protein derivatisation and conjugation
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United States of America Patent
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-
Dec 22, 2015
Grant Date -
Jun 4, 2015
app pub date -
Dec 23, 2014
filing date -
Feb 23, 2005
priority date (Note) -
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status (Latency Note)
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Abstract
Derivatives of PSAs are synthesized, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.
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International Classification(s)
- 2014 Application Filing Year
- C07H Class
- 1109 Applications Filed
- 1014 Patents Issued To-Date
- 91.44 % Issued To-Date
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- 0 Citation Count
- C07H Class
- 0 % this patent is cited more than
- 10 Age
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| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jun 22, 2027 |
