Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response

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United States of America Patent

PATENT NO 9206430
SERIAL NO

13731492

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Abstract

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The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

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Patent Owner(s)

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IDERA PHARMACEUTICALS INCCAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agrawal, Sudhir Cambridge, US 223 8509
Bhagat, Lakshmi Cambridge, US 54 1124
Kandimalla, Ekambar R Cambridge, US 70 1668
Li, Yukui Cambridge, US 15 412
Wang, Daqing Cambridge, US 91 766
Yu, Dong Cambridge, US 354 6818
Zhu, FuGang Cambridge, US 11 199

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