Probes comprising fluorescent artificial nucleobases and use thereof for detection of single base alteration

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United States of America Patent

PATENT NO 9206218
APP PUB NO 20120208178A1
SERIAL NO

13394729

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Abstract

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The present invention relates to forced intercalation probes (FIT-probes) comprising at least one nucleoside analog which comprises at least a fluorescent artificial nucleobase directly bound to a carbon of a modified sugar moiety wherein said modified sugar moiety is a carba-sugar or an amino acid nucleic acid (AANA). Thereby the nucleoside analog is incorporated into DNA or RNA in the place of a single native base.

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Patent OwnerAddress
HUMBOLDT-UNIVERSITAT ZU BERLIN10099 BERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bethge, Lucas Potsdam, DE 20 27
Hainke, Sven Berlin, DE 1 0
Seitz, Oliver Berlin, DE 9 17

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