Process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline
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United States of America Patent
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Dec 8, 2015
Grant Date -
Jul 17, 2014
app pub date -
Jun 5, 2012
filing date -
Jun 6, 2011
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Abstract
The present invention provides a new process of synthesis of a polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline of Formula I. Said quinoline compound is substantially pure of any impurities. The present invention further provides the use of the above-mentioned polymorph of 7-chloro-4-(piperazin-1-yl)-quinoline in the synthesis of piperaquine or one of its pharmaceutically acceptable salts.
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