Enzyme-degradable polymer and application thereof
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United States of America Patent
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Dec 1, 2015
Grant Date -
Aug 28, 2014
app pub date -
May 24, 2011
filing date -
May 24, 2011
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Abstract
The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer. The present invention also provides hydrogels, nano-particles, fluorescent dye-labeled enzyme substrates and kits (packages) for detection or activity-analysis of biological enzymes based on the enzyme-degradable polymer. The formula of the enzyme-degradable polymer is P1-(aa)N-(AA)n-X X=[formula 1] wherein, (aa)N is a non-enzyme substrate domain, the N aa may be different (no correlation), and N is a non-negative integer; (AA)n is an enzyme substrate domain, the n AA may be different, and n is a non-negative integer; P1 is a protecting group of α-amino or functional group; P2 is a protecting group of α-amino; P3 is —NH2, a small molecule compound or a fragment of a polymer.
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