Thiazolidine linker for the conjugation of drugs to antibodies
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United States of America Patent
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Dec 1, 2015
Grant Date -
Nov 21, 2013
app pub date -
Mar 25, 2013
filing date -
Sep 29, 2010
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Abstract
In one aspect, there is provided a protein-drug conjugate compound comprising a protein covalently attached by a linker to one or more drug moieties, wherein the linker has a half-life of from 1 hour to 50 hours in phosphate buffered saline at 37° C. A carbonyl derivative of LU103793 is also described that can be used in a protein-drug conjugate compound comprising an antibody covalently attached by a linker to the drug moiety comprising, consisting or consisting essentially of the carbonyl derivative.
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