Stable pharmaceutical formulation of cabazitaxel
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United States of America Patent
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Dec 1, 2015
Grant Date -
Jun 19, 2014
app pub date -
Aug 15, 2013
filing date -
Aug 15, 2012
priority date (Note) -
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Abstract
The present invention relates to a stable liquid cabazitaxel formulation in an enclosed container. The enclosed container comprises a liquid phase and an gaseous phase, wherein the liquid phase comprises cabazitaxel, polysorbate 80, ethanol, and one or more pH adjusters to maintain pH about 2.8-6.0, and the gaseous phase is saturated with CO2. The present invention is also directed to a process for preparing the enclosed liquid pharmaceutical composition container.
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