Stabilized alpha-galactosidase and uses thereof
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United States of America Patent
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Nov 24, 2015
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app pub date -
Mar 2, 2011
filing date -
Nov 17, 2009
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Abstract
Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
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