Pegylated analogue protein or canine urate oxidase, preparation method and use thereof
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United States of America Patent
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Nov 24, 2015
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Mar 6, 2014
app pub date -
Feb 14, 2012
filing date -
Feb 14, 2011
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Abstract
Provided are a PEGylated analogue protein of canine urate oxidase, preparation method and use thereof. The analogue protein of canine urate oxidase is a canine urate oxidase, or a chimeric protein comprising part of the amino acid sequence of a canine urate oxidase and part of the amino acid sequence of a human urate oxidase, or a mutant protein thereof. The PEGylated analogue protein of canine urate oxidase and pharmaceutical compositions thereof according to the present invention can be used for the prevention and/or treatment of hyperuricemia and chronic gout.
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