Highly functional enzyme having alpha-galactosidase activity
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United States of America Patent
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Nov 24, 2015
Grant Date -
Jun 19, 2014
app pub date -
Jan 23, 2014
filing date -
Nov 18, 2005
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Abstract
The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein having α-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquired α-galactosidase activity by changing the structure of the active site of wild-type human α-N-acetylgalactosaminidase.
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