Hydrolases, nucleic acids encoding them and methods for making and using them

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United States of America Patent

PATENT NO 9193962
APP PUB NO 20140128590A1
SERIAL NO

13619974

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Abstract

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The invention provides hydrolases, polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention is directed to polypeptides, e.g., enzymes, having a hydrolase activity, e.g., an esterase, acylase, lipase, phospholipase (e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity) or protease activity, including thermostable and thermotolerant hydrolase activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The hydrolase activities of the polypeptides and peptides of the invention include esterase activity, lipase activity (hydrolysis of lipids), acidolysis reactions (to replace an esterified fatty acid with a free fatty acid), transesterification reactions (exchange of fatty acids between triglycerides), ester synthesis, ester interchange reactions, phospholipase activity and protease activity (hydrolysis of peptide bonds). The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts, including the manufacture of cosmetics and nutraceuticals. In another aspect, the polypeptides of the invention are used to synthesize enantiomerically pure chiral products.

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Patent Owner(s)

Patent OwnerAddress
DSM IP ASSETS B VHOLLAND HEERLEN HEERLEN LIMBURG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bornscheuer, Uwe T Greifswald, DE 9 78
Hitchman, Tim Encinitas, US 23 161
Lyon, Jonathan San Diego, US 21 156
Weiner, David Del Mar, US 142 723
Wongsakul, Sirirung Chiangmai, TH 3 50

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