Reducing conjugative plasmids in bacteria
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United States of America Patent
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Nov 24, 2015
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app pub date -
Mar 10, 2009
filing date -
Mar 10, 2008
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Abstract
The present invention provides methods and compositions to reduce prevalence of plasmids in microbial colonies, including infections, and includes therapeutic compositions, methods for treatment of infections, and methods for identifying additional such compositions. Means are provided to reduce the copy numbers of antibiotic resistance genes, and to confer phage binding to cells lacking receptors for those phage.
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