TFEB variants and uses thereof
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United States of America Patent
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Nov 24, 2015
Grant Date -
Nov 12, 2015
app pub date -
Jul 29, 2015
filing date -
Mar 7, 2011
priority date (Note) -
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Abstract
The invention refers to TFEB related molecules, as variants, mutants, truncated proteins, chimeras etc. that are constitutively localized in the nucleus of a eukaryote cell. Such molecules have a therapeutic applicability in all of disorders that need of an induction of the cell authophagic/lysosomal system, as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, muscle diseases and metabolic diseases.
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