Method for predicting the presence of reproductive cells in TESTIS
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United States of America Patent
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Nov 17, 2015
Grant Date -
Oct 9, 2014
app pub date -
Oct 31, 2012
filing date -
Nov 2, 2011
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Abstract
Testicular germline markers and their use for predicting the presence or not of reproductive cells in testis of an infertile or hypo fertile male subject are provided. More particularly, identification of specific protein biomarkers of post-meiotic germ cells in the human seminal plasma was carried out by an integrative genomics approach. It was demonstrated that the presence of such biomarkers could be monitored in the seminal plasma of azoospermic subjects in order to select for a testis biopsy and testicular sperm extraction (TESE) only subjects for which there are high probabilities to find reproductive cells. The results indicate the analysis of seminal plasma is a non-invasive approach for predicting the presence of reproductive cells.
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