Alphavirus and alphavirus replicon particle formulations and methods
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United States of America Patent
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Nov 17, 2015
Grant Date -
Jul 28, 2011
app pub date -
Jan 24, 2011
filing date -
Nov 3, 2006
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Abstract
Disclosed are methods for preparing dried (preferably lyophilized) preparations comprising a population of alphaviruses or alphavirus replicon particles, a sugar or polyol, a surfactant and a salt and preparations made by these methods, both in the dried form but also as liquids prior to drying or after reconstituting dried preparations. These preparations may further comprise a plasticizer and/or a bulking agent. These preparations are readily reconstituted, with little or no loss in infectivity of the viruses or replicon particles.
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