Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
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United States of America Patent
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Nov 17, 2015
Grant Date -
May 14, 2009
app pub date -
Apr 10, 2006
filing date -
Apr 8, 2005
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Abstract
The present invention relates to protease resistant mutants of human growth hormone, which contain newly introduced proteolysis resistant mutations and N-linked or O-linked glycosylation site(s), such that these recombinantly produced polypeptides have glycosylation patterns distinctly different from that of the naturally occurring human growth hormone. The polynucleotide coding sequences for the mutants, expression cassettes comprising the coding sequences, cells expressing the mutants, and methods for producing the mutants are also disclosed. Further disclosed are pharmaceutical compositions comprising the mutants and method for using the mutants.
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