Multi-epitopic vaccine
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United States of America Patent
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Nov 17, 2015
Grant Date -
Sep 13, 2012
app pub date -
Mar 9, 2012
filing date -
Mar 11, 2011
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Abstract
The present invention relates to isolated polypeptides comprising: (i) a protein transduction domain consisting of ZEBRA or a fragment thereof that retains the capacity of internalization, (ii) at least one CD4+ epitope; and (iii) at least one CD8+ epitope. It also relates to antigen presenting cells loaded with said polypeptides, and the use thereof in immunotherapy including prevention and/or treatment of cancers or infectious diseases.
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