Process for preparing chiral dipeptidyl peptidase-IV inhibitors

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United States of America Patent

PATENT NO 9187488
APP PUB NO 20140107346A1
SERIAL NO

14119063

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Abstract

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A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.

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Patent Owner(s)

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MERCK SHARP & DOHME LLC126 EAST LINCOLN AVENUE RAHWAY NJ 07065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bremeyer, Nadine Hoddesdon, GB 5 5
Chen, Qinghao Edison, US 12 12
Dunn, Robert F Towaco, US 19 140
Janey, Jacob M New York, US 14 56
Kuethe, Jeffrey T Somerset, US 8 38
Lieberman, David Hoddesdon, GB 32 317
Moment, Aaron J Middletown, US 4 3
Scott, Jeremy Hoddesdon, GB 16 102
Sheen, Faye Hoddesdon, GB 6 11
Tan, Lushi Edison, US 25 64
Zacuto, Michael J Jersey City, US 11 20

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