Use of transcriptome modifying agents and chemotherapy or radiotherapy against cancer

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United States of America Patent

PATENT NO 9186339
APP PUB NO 20090196851A1
SERIAL NO

12093906

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Abstract

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The use of transcriptome-modifying agents is disclosed in order to prevent malignant cells from undergoing the necessary genetic changes in order to combat cell insult and survive chemotherapy or radiotherapy. The combination of transcriptome-modifying agents comprises agents that inhibit the DNA methylation machinery plus a substance that inhibits histone deacetylation. A treatment kit is disclosed which includes an effective dose of hydralazine and valproic acid or a salt of same in the case of magnesium valproate, which is intended for use with radiotherapy or chemotherapy in the treatment of patients cancer.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO9 PISO DE LA TORRE DE RECTORIA CIUDAD UNIVERSITARIA DELEGACION COYOACAN MEXICO CITY C P 04510

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Flores, Luis Estrada Col. Torielo Guerra, MX 2 0
Gonzalez, Alfonso Dueñas México D.F., MX 1 0

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