Methods for diagnosis, prognosis and methods of treatment

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United States of America Patent

PATENT NO 9182385
APP PUB NO 20120309029A1
SERIAL NO

13493857

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. The physiological status of a cell can be determined by comparing the intracellular status of one or more activation elements (e.g. the phosphorylation status of a signaling molecule) in a cell (e.g. a cancer cell) to that of another cell (e.g. a normal cell). The physiological status of a cell can be further classified by adding one or more modulators (e.g. an inhibitor or activator) to the cell in question. In some embodiments, the invention is directed to methods of determining a phenotypic profile of a population of cells.

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Patent Owner(s)

Patent OwnerAddress
NODALITY INC170 HARBOR WAY SOUTH SAN FRANCISCO CA 94080

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cohen, Aileen C Palo Alto, US 4 64
Fantl, Wendy J San Francisco, US 40 544
Francis-Lang, Helen L San Francisco, US 4 64
Perez, Omar D San Francisco, US 37 780
Putta, Santosh K Foster City, US 21 362

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