Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants
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United States of America Patent
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Nov 10, 2015
Grant Date -
Jan 24, 2013
app pub date -
Feb 24, 2011
filing date -
Feb 24, 2010
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Abstract
The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
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